Comparative studies on the absorption mechanism of p-aminobenzoic acid and p-acetamidobenzoic acid from the rat intestine.
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چکیده
منابع مشابه
Metabolic conjugations of p-aminobenzoic acid in the rat.
The acetylation of p-aminobenzoic acid (PAB) (2) and of sulfanilamide (3) by the rat has been shown to depend upon an adequate supply of pantothenic acid, a constituent of the coenzyme A molecule (4). In addition the extent of acetylation is decreased by giving large amounts of PAB with reference to the size of the animal (5, 6) and to a smaller extent by a deficiency of riboflavin (5). The pre...
متن کاملMechanism of competitive inhibition of p-aminobenzoic acid oxidation by p-aminosalicylic acid.
The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...
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15 صفحه اولTHE ISOLATION OF p-AMINOBENZOIC ACID FROM YEAST
The present investigation is primarily concerned with the isolation of p-aminobenzoic acid from yeast. The presence of this substance in yeast was adumbrated by Woods (1) who made the important discovery that. this aromatic amino acid possesses the unique propcity of antagonizing the bsctcriostat~ic action of sulfanilamidt? and that the component. of yeast extracts which exerts a similar antisu...
متن کاملSeparation of p-Aminobenzoic Acid Derivatives
According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1979
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.2.177